| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Clima Temperado. |
|
Data corrente: |
04/08/2023 |
|
Data da última atualização: |
04/08/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
PEREIRA, R. S.; COSTA, V. V.; GOMES, G. L. M.; CAMPANA, P. R. V.; PÁDUA, R. M. de; BARBOSA, M.; OKI, Y.; HEIDEN, G.; FERNANDES, G. W.; OLIVEIRA, D. M. de; SOUZA, D. G.; TEIXEIRA, M. M.; BRAGA, F. C. |
|
Afiliação: |
ROSÂNGELA SANTOS PEREIRA, Universidade Federal de Minas Gerais; VIVIAN VASCONCELOS COSTA, Universidade Federal de Minas Gerais; GABRIEL LUIZ MENEZES GOMES, Universidade Federal de Minas Gerais; PRISCILLA RODRIGUES VALADARES CAMPANA, Universidade Federal de Minas Gerais; RODRIGO MAIA DE PÁDUA, Universidade Federal de Minas Gerais; MILTON BARBOSA, Universidade Federal de Minas Gerais; YUMI OKI, Universidade Federal de Minas Gerais; GUSTAVO HEIDEN, CPACT; GERALDO WILSON FERNANDES, Universidade Federal de Minas Gerais; DJALMA MENEZES DE OLIVEIRA, Universidade Estadual do Sudoeste da Bahia; DANIELE G. SOUZA, Universidade Federal de Minas Gerais; MAURO MARTINS TEIXEIRA, Universidade Federal de Minas Gerais; FERNÃO CASTRO BRAGA, Universidade Federal de Minas Gerais. |
|
Título: |
Anti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells. |
|
Ano de publicação: |
2022 |
|
Fonte/Imprenta: |
Chemistry & Biodiversity, v. 19, n. 4, e202100842, April 2022. |
|
DOI: |
https://doi.org/10.1002/cbdv.202100842 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively. MenosZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes w... Mostrar Tudo |
|
Thesagro: |
Biodiversidade; Extrato Vegetal; Vírus. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1155672/1/Artigo-Anti8208Zika-Virus-Activity-of-Plant-Extracts.pdf
|
|
Marc: |
LEADER 02560naa a2200313 a 4500
001 2155672
005 2023-08-04
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1002/cbdv.202100842$2DOI
100 1 $aPEREIRA, R. S.
245 $aAnti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells.$h[electronic resource]
260 $c2022
520 $aZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively.
650 $aBiodiversidade
650 $aExtrato Vegetal
650 $aVírus
700 1 $aCOSTA, V. V.
700 1 $aGOMES, G. L. M.
700 1 $aCAMPANA, P. R. V.
700 1 $aPÁDUA, R. M. de
700 1 $aBARBOSA, M.
700 1 $aOKI, Y.
700 1 $aHEIDEN, G.
700 1 $aFERNANDES, G. W.
700 1 $aOLIVEIRA, D. M. de
700 1 $aSOUZA, D. G.
700 1 $aTEIXEIRA, M. M.
700 1 $aBRAGA, F. C.
773 $tChemistry & Biodiversity$gv. 19, n. 4, e202100842, April 2022.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Clima Temperado (CPACT) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Soja. |
|
Data corrente: |
13/08/2020 |
|
Data da última atualização: |
13/08/2020 |
|
Tipo da produção científica: |
Circular Técnica |
|
Autoria: |
GODOY, C. V.; UTIAMADA, C. M.; MEYER, M. C.; CAMPOS, H. D.; LOPES, I. de O. N.; DIAS, A. R.; MUHL, A.; WESP-GUTERRES, C.; PIMENTA, C. B.; ANDRADE JUNIOR, E. R. de; MORESCO, E.; KONAGESKI, F. T.; BONANI, J. C.; ROY, J. M. T.; GRIGOLLI, J. F. J.; NUNES JUNIOR, J.; ARRUDA, J. H.; NAVARINI, L.; BELUFI, L. M. de R.; SILVA, L. H. C. P. da; SATO, L. N.; GOUSSAIN JUNIOR, M. M.; SENGER, M.; MULLER, M. A.; DEBORTOLI, M. P.; MARTINS, M. C.; TORMEN, N. R.; BALARDIN, R. S.; MADALOSSO, T.; KONAGESKI, T. F.; CARLIN, V. J. |
|
Afiliação: |
CLAUDIA VIEIRA GODOY, CNPSO; ENGENHEIRO-AGRÔNOMO, TAGRO, LONDRINA, PR; MAURICIO CONRADO MEYER, CNPSO; ENGENHEIRO-AGRÔNOMO, UNIRV, RIO VERDE, GO; IVANI DE OLIVEIRA NEGRAO LOPES, CNPSO; ENGENHEIRO-AGRÔNOMO, FUNDAÇÃO CHAPADÃO, CHAPADÃO DO SUL, MS; ENGENHEIRA-AGRÔNOMA, CENTRO DE PESQUISA AGRÍCOLA COPACOL, CAFELÂNDIA, PR; BIÓLOGA, COOPERATIVA CENTRAL GAÚCHA LTDA., CRUZ ALTA, RS; ENGENHEIRA-AGRÔNOMA, EMATER, GOIÂNIA, GO; ENGENHEIRO-AGRÔNOMO, INSTITUTO MATO-GROSSENSE DO ALGODÃO, CUIABÁ, MT; TÉCNICO EM AGROPECUÁRIA, 3M EXPERIMENTAÇÃO AGRÍCOLA, PONTA GROSSA, PR; ENGENHEIRA-AGRÔNOMA, RURAL TÉCNICA EXPERIMENTOS, QUERÊNCIA, MT; ENGENHEIRO-AGRÔNOMO, COAMO, CAMPO MOURÃO, PR; ENGENHEIRO AGRÔNOMO, CENTRO DE PESQUISA AGRÍCOLA COPACOL, CAFELÂNDIA, PR; ENGENHEIRO-AGRÔNOMO, FUNDAÇÃO MS PARA PESQUISA E DIFUSÃO DE TECNOLOGIAS AGROPECUÁRIAS, MARACAJU, MS; ENGENHEIRO-AGRÔNOMO, CENTRO TECNOLÓGICO PARA PESQUISAS AGROPECUÁRIAS - CTPA, GOIÂNIA, GO; ENGENHEIRA-AGRÔNOMA, FUNDAÇÃO MATO GROSSO, RONDONÓPOLIS, MT; ENGENHEIRO-AGRÔNOMO, PESQUISADOR DA PLANTA CONHECIMENTO/HA, PASSO FUNDO, RS; ENGENHEIRA-AGRÔNOMA, FUNDAÇÃO DE PESQUISA E DESENVOLVIMENTO TECNOLÓGICO RIO VERDE, LUCAS DO RIO VERDE, MT; ENGENHEIRO-AGRÔNOMO, AGRO CARREGAL PESQUISA E PROTEÇÃO DE PLANTAS EIRELI, RIO VERDE, GO; ENGENHEIRO-AGRÔNOMO, TAGRO, LONDRINA, PR; ENGENHEIRO-AGRÔNOMO, ASSIST CONSULTORIA E EXPERIMENTAÇÃO AGRONÔMICA LTDA., CAMPO VERDE, MT; ENGENHEIRA-AGRÔNOMA, 3M EXPERIMENTAÇÃO AGRÍCOLA, PONTA GROSSA, PR; ENGENHEIRA-AGRÔNOMA, FUNDAÇÃO MATO GROSSO, RONDONÓPOLIS, MT; ENGENHEIRA-AGRÔNOMA, INSTITUTO PHYTUS, SANTA MARIA, RS; ENGENHEIRA- AGRÔNOMA, CÍRCULO VERDE ASSESSORIA AGRONÔMICA E PESQUISA, LUÍS EDUARDO MAGALHÃES, BA; ENGENHEIRO-AGRÔNOMO, INSTITUTO PHYTUS, PLANALTINA, DF; ENGENHEIRO-AGRÔNOMO, UNIVERSIDADE FEDERAL DE SANTA MARIA, SANTA MARIA, RS; ENGENHEIRO-AGRÔNOMO, CENTRO DE PESQUISA AGRÍCOLA COPACOL, CAFELÂNDIA, PR; ENGENHEIRO-AGRÔNOMO, RURAL TÉCNICA EXPERIMENTOS AGRONÔMICOS LTDA., QUERÊNCIA, MT; ENGENHEIRO-AGRÔNOMO, AGRODINÂMICA, TANGARÁ DA SERRA, MT. |
|
Título: |
Eficiência de fungicidas para o controle da ferrugem-asiática da soja, Phakopsora pachyrhizi, na safra 2019/2020: resultados sumarizados dos ensaios cooperativos. |
|
Ano de publicação: |
2020 |
|
Fonte/Imprenta: |
Londrina: Embrapa Soja, 2020. |
|
Páginas: |
19 p. |
|
Série: |
(Embrapa Soja. Circular técnica, 160). |
|
Idioma: |
Português |
|
Thesagro: |
Ferrugem; Fungicida; Phakopsora Pachyrhizi; Soja. |
|
Thesaurus NAL: |
Fungicides; Soybean rust. |
|
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/215288/1/CT-160-OL.pdf
|
|
Marc: |
LEADER 01594nam a2200553 a 4500
001 2124331
005 2020-08-13
008 2020 bl uuuu u0uu1 u #d
100 1 $aGODOY, C. V.
245 $aEficiência de fungicidas para o controle da ferrugem-asiática da soja, Phakopsora pachyrhizi, na safra 2019/2020$bresultados sumarizados dos ensaios cooperativos.$h[electronic resource]
260 $aLondrina: Embrapa Soja$c2020
300 $a19 p.
490 $a(Embrapa Soja. Circular técnica, 160).
650 $aFungicides
650 $aSoybean rust
650 $aFerrugem
650 $aFungicida
650 $aPhakopsora Pachyrhizi
650 $aSoja
700 1 $aUTIAMADA, C. M.
700 1 $aMEYER, M. C.
700 1 $aCAMPOS, H. D.
700 1 $aLOPES, I. de O. N.
700 1 $aDIAS, A. R.
700 1 $aMUHL, A.
700 1 $aWESP-GUTERRES, C.
700 1 $aPIMENTA, C. B.
700 1 $aANDRADE JUNIOR, E. R. de
700 1 $aMORESCO, E.
700 1 $aKONAGESKI, F. T.
700 1 $aBONANI, J. C.
700 1 $aROY, J. M. T.
700 1 $aGRIGOLLI, J. F. J.
700 1 $aNUNES JUNIOR, J.
700 1 $aARRUDA, J. H.
700 1 $aNAVARINI, L.
700 1 $aBELUFI, L. M. de R.
700 1 $aSILVA, L. H. C. P. da
700 1 $aSATO, L. N.
700 1 $aGOUSSAIN JUNIOR, M. M.
700 1 $aSENGER, M.
700 1 $aMULLER, M. A.
700 1 $aDEBORTOLI, M. P.
700 1 $aMARTINS, M. C.
700 1 $aTORMEN, N. R.
700 1 $aBALARDIN, R. S.
700 1 $aMADALOSSO, T.
700 1 $aKONAGESKI, T. F.
700 1 $aCARLIN, V. J.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Soja (CNPSO) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
